Awatef Allouch

This study identifies a signaling pathway in macrophages where ionizing radiation induces mitochondrial fragmentation and cGAS activation, leading to proinflammatory activation, which is modulated by the P2Y2 purinergic receptor.

This study shows that AGuIX nanoparticles and their combination with ionizing radiation induce proinflammatory reprogramming of tumor-associated macrophages via AMPK-dependent mitochondrial fragmentation.