Author

Jean‐Luc Perfettini

InsermORCID 0000-0002-2427-2604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Ali Mostefa-Kara· 1 shared Anaïs Chapel· 1 shared Audrey PaolettiiD· 1 shared Aurélia Deva NathaniD· 1 shared Awatef AllouchiD· 1 shared Emie Gutierrez-MateyroniD· 1 shared Thanh Trang Cao-Pham· 1 shared Yara Bou GhosniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperImmunology

Ali Mostefa-Kara

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintDec 19, 2024

P2Y2 purinergic receptor and DNA sensor cGAS dictate ionizing radiation-mediated proinflammatory macrophage activation

Ali Mostefa-Kara, Aurélia Deva Nathan, Audrey Paoletti…·Jean‐Luc Perfettini

This study identifies a signaling pathway in macrophages where ionizing radiation induces mitochondrial fragmentation and cGAS activation, leading to proinflammatory activation, which is modulated by the P2Y2 purinergic receptor.

1 citation

mouseproteomics

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