BLOC1S1 regulates autolysosomal and exosomal dynamics during CD4⁺ T cell differentiation
Rahul Sharma, Zulfeqhar Ali Syed, Sandeep K Vishwakarma, Kaiyuan Wu, Kim Han, Anand K Gupta, Christian A. Combs, Michael N. Sack
This study shows BLOC1S1 deficiency in CD4+ T cells leads to altered lysosomal and exosomal dynamics, enhancing Th2 immune responses through exosome-mediated cytokine export.
bioRxiv · May 18, 2026 · PreprintImmunology