The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen
Tathiane Maistro Malta, Thaís S. Sabedot, Natalia S. Morosini, Indrani Datta, Luciano Garofano, Wies Vallentgoed, Frederick S. Varn, Kenneth Aldape, Fulvio D’Angelo, Spyridon Bakas, Jill S. Barnholtz‐Sloan, Hui Kong Gan, Mohammad Hasanain, Ann‐Christin Hau, Kevin C. Johnson, , Peter S. LaViolette
This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.
Cancer Research · Dec 20, 2023Peer-reviewedGenomics