Author

Andreas Jakob

Masaryk University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Andrew J. deMelloiD· 1 shared Ankit JainiD· 1 shared Christoffel P. S. BadenhorstiD· 1 shared David BednářiD· 1 shared David Damborsky· 1 shared David R. KovariD· 1 shared Flora W. Y. Chiu· 1 shared Hana FaldynováiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrew J. deMelloORCID

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1 paper

Recent·Most cited

Uncovering Functional Distant Mutations by Ultra-High-Throughput Screening of Dehalogenases

Hana Faldynová, David R. Kovar, Ankit Jain, Michaela Slanska, Marek Martínek, Andreas Jakob, Marie Šulová, Michal Vasina, Joan Planas-Iglesias, Sérgio M. Marques, Naina Verma, Pavel Vaňáček, David Damborsky, Christoffel P. S. Badenhorst, Tomáš Buryška, , Zbyněk Prokop

This study uses ultrahigh-throughput screening to identify mutations in dehalogenases that modulate substrate access and binding, revealing distal functional effects on enzyme dynamics.

ACS Catalysis · Oct 2, 2026Peer-reviewedBiochemistry