Andrew J. deMello

Unattended droplet-microfluidic Bayesian optimization of a glycerol detection cascade matched design of experiments (DoE) with one third of the conditions; a second cascade used DoE with Raman readout.

This study uses ultrahigh-throughput screening to identify mutations in dehalogenases that modulate substrate access and binding, revealing distal functional effects on enzyme dynamics.

This study reports co-crystal structures of a bioluminescent energy-transfer complex in Renilla reniformis, revealing the spatial arrangement of donor-acceptor chromophores and their role in efficient radiationless energy transfer.

The paper uses droplet single-cell CRISPR screening to identify regulators of T cell-mediated target-cell killing and finds that mTORC1 modulation enhances cytotoxic activity.

This study identifies conformational dynamics as a key determinant of luciferase catalytic efficiency and light-emission stability, revealing a trade-off between oxygen affinity and enzyme longevity.

The paper shows that cell size predicts physiological germ cell death in C. elegans, regulated by actomyosin contractility at apical rachis bridges.

The paper identifies a reciprocal EGFR signaling mechanism in the C. elegans anchor cell that ensures precise alignment and connection between the uterus and vulva during development.

This paper characterizes CRANAD-2 for detecting amyloid-beta deposits in Alzheimer's mouse models using multi-spectral optoacoustic tomography and fluorescence imaging.

This paper introduces a microfluidic imaging method for long-term, stable, and parallel live-imaging of C. elegans larval development, enabling observation of previously inaccessible processes.