Michaela Slanska

This study uses ultrahigh-throughput screening to identify mutations in dehalogenases that modulate substrate access and binding, revealing distal functional effects on enzyme dynamics.

This paper enhances fluorinase catalytic efficiency by engineering mutants and optimizing reaction conditions, achieving a 60-fold increase in turnover rate.

This paper engineers a biotin-independent Saccharomyces cerevisiae strain by bypassing acetyl-CoA carboxylase, enabling growth without biotin and improved malonate utilization.