A Consensus Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation
Erik C. B. Johnson, Eric B. Dammer, Duc Minh Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A. Higginbotham, Andrew Guajardo, Bartholomew White, Juan Carlos Troncoso, Madhav Thambisetty, Thomas Jude Montine, Edward B. Lee, John Q. Trojanowski, Thomas G. Beach, , Nicholas T. Seyfried
The paper identifies protein network modules in Alzheimer's disease brains and cerebrospinal fluid that are associated with energy metabolism and neuroinflammation, suggesting potential biomarkers and therapeutic targets.
Nature Medicine · Apr 13, 2020Peer-reviewedSystems Biology