Author

Lenora A. Higginbotham

Emory UniversityORCID 0000-0002-8694-9211Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 4 Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:proteomics· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Nicholas T. SeyfriediD· 6 shared Allan I. LeveyiD· 5 shared James J. LahiD· 5 shared David Alan BennettiD· 4 shared Eric B. DammeriD· 4 shared Duc Minh DuongiD· 3 shared Erik C. B. JohnsoniD· 3 shared Luming Yin· 3 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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6 shared papersSystems Biology

Nicholas T. SeyfriedORCID

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6 papers

Recent·Most cited

Multiplex Proteomics of Lewy Body Dementia Reveals Cerebrospinal Fluid Biomarkers of Clinical and Neuropathological Heterogeneity

Lenora A. Higginbotham, Saima Rathore, Anantharaman Shantaraman, Qi Guo, Edward J. Fox, Pritha Bagchi, Fang Wu, Marisa N. Denkinger, Davron Hanley, Nicholas James Ashton, the Alzheimer’s Disease Neuroimaging Initiative, Erik C.B. Johnson, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

This study uses multiplex proteomics to identify CSF biomarkers of clinical and neuropathological heterogeneity in Lewy body dementia.

bioRxiv · Jun 10, 2025 · PreprintSystems Biology

Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer's Disease

Anantharaman Shantaraman, Eric B. Dammer, Obiadada Ugochukwu, Duc Minh Duong, Luming Yin, E. Kathleen Carter, Marla Gearing, Alice S. Chen‐Plotkin, Edward B. Lee, John Q. Trojanowski, David Alan Bennett, James J. Lah, Allan I. Levey, Nicholas T. Seyfried, Lenora A. Higginbotham

This study identifies distinct presynaptic protein networks in Lewy body dementia that differ from Alzheimer's disease using network proteomics.

Molecular Neurodegeneration · Aug 6, 2024Peer-reviewedSystems Biology

Transcriptomic network analysis of brain and bone reveals shared molecular mechanisms underlyingAlzheimer's Disease and related dementias and Osteoporosis

Archana Nagarajan, Jason Laird, Obiadada Ugochukwu, Sjur Reppe, Kaare M. Gautvik, Ryan D. Ross, David Alan Bennett, Clifford james Rosen, Douglas P. Kiel, Lenora A. Higginbotham, Nicholas T. Seyfried, Christine W. Lary

The paper identifies shared molecular mechanisms between Alzheimer's Disease and Osteoporosis using transcriptomic network analysis across brain and bone tissues.

bioRxiv · Oct 26, 2023 · PreprintNeuroscience

Unbiased Classification of the Human Brain Proteome Resolves Distinct Clinical and Pathophysiological Subtypes of Cognitive Impairment

Lenora A. Higginbotham, Kathleen Carter, Eric B. Dammer, Rafi U. Haque, Erik C. B. Johnson, Duc M. Duong, Luming Yin, Philip L. De Jager, David Alan Bennett, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

The paper uses proteomic profiling to classify cognitive impairment subtypes in human brain tissues, identifying distinct molecular patterns associated with different clinical outcomes.

bioRxiv · Jul 22, 2022 · PreprintNeuroscience

Integrated Proteomics Reveals Brain-Based Cerebrospinal Fluid Biomarkers in Asymptomatic and Symptomatic Alzheimer’s Disease

Lenora A. Higginbotham, Lingyan Ping, Eric B. Dammer, Duc Minh Duong, Maotian Zhou, Marla Gearing, Cheyenne D. Hurst, Jonathan D. Glass, Stewart Alan Factor, Erik C. B. Johnson, Ihab M. Hajjar, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

The paper identifies brain-linked CSF biomarkers in Alzheimer’s disease using proteomics, revealing altered levels in both brain and CSF across different disease stages.

Science Advances · Oct 21, 2020Peer-reviewedSystems Biology

A Consensus Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation

Erik C. B. Johnson, Eric B. Dammer, Duc Minh Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A. Higginbotham, Andrew Guajardo, Bartholomew White, Juan Carlos Troncoso, Madhav Thambisetty, Thomas Jude Montine, Edward B. Lee, John Q. Trojanowski, Thomas G. Beach, , Nicholas T. Seyfried

The paper identifies protein network modules in Alzheimer's disease brains and cerebrospinal fluid that are associated with energy metabolism and neuroinflammation, suggesting potential biomarkers and therapeutic targets.

Nature Medicine · Apr 13, 2020Peer-reviewedSystems Biology