Identification of Omaveloxolone as An Endoplasmic Reticulum Associated Degradation Inhibitor That Induces Early Apoptotic Signaling in Multiple Myeloma
Erin M. Kropp, Sho Matono, Olivia Y. Wang, Aaron M. Robida, Malathi Kandarpa, Jineigh L. Grant, Bryndon J. Oleson, Andrew J. Alt, Moshe Talpaz, Matthew James Pianko, Qing Li
This paper identifies omaveloxolone as an ERAD inhibitor that induces apoptosis in multiple myeloma cells through caspase 8 and DISC signaling.
bioRxiv · Apr 2, 2025 · PreprintCell Biology