PERK Signaling Maintains Hematopoietic Stem Cell Pool Integrity under Endoplasmic Reticulum Stress by Promoting Proliferation
Manxi Zheng, Qinlu Peng, Erin M. Kropp, Zhejuan Shen, Suxuan Liu, Zhengyou Yin, Sho Matono, Takao Iwawaki, Xiang Wang, Ken Inoki, Yang Mei, Qing Li, Lu Liu
This study shows PERK signaling promotes HSC proliferation under ER stress to maintain stem cell pool integrity by activating mTOR, without relying on apoptosis.
Blood · May 28, 2025Peer-reviewedCell Biology