Qing Li

Acute Myeloid Leukemia Relapse after Bromodomain Inhibitor Treatment or Chemotherapy is Characterized by Myc-Ras Transcriptional Remodeling

This study shows that AML relapse after BET inhibitor or chemotherapy involves Myc-Ras transcriptional changes, highlighting transcriptional plasticity in relapsed leukemias.

A neuroendocrine principle: Pancreatic islets actively shape sympathetic innervation

The paper shows pancreatic islets actively shape sympathetic innervation, with Reg2 and Reg3β promoting nerve regeneration and islet function.

PERK Signaling Maintains Hematopoietic Stem Cell Pool Integrity under Endoplasmic Reticulum Stress by Promoting Proliferation

This study shows PERK signaling promotes HSC proliferation under ER stress to maintain stem cell pool integrity by activating mTOR, without relying on apoptosis.

Identification of the role of SEL1L in platelet function through a multi-species genetic investigation

The paper identifies SEL1L's role in platelet function across species, showing it is necessary for platelet adhesion to injured sites.

Identification of Omaveloxolone as An Endoplasmic Reticulum Associated Degradation Inhibitor That Induces Early Apoptotic Signaling in Multiple Myeloma

This paper identifies omaveloxolone as an ERAD inhibitor that induces apoptosis in multiple myeloma cells through caspase 8 and DISC signaling.

A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond Blackfan Anemia

This paper describes a novel Rpl5 mutation in mice that models Diamond Blackfan Anemia with variable penetrance and anemia remission.