Optogenetic inhibition of Gα signalling alters and regulates circuit functionality and early circuit formation
Jayde L. Lockyer, Andrew Reading, Silvia Vicenzi, Caroline Delandre, Owen J. Marshall, Robert Gasperini, Lisa C Foa, John Y. Lin
This paper develops and validates an optogenetic tool, PiGM-Iq, to inhibit Gq signaling and demonstrates its effects on behavior, axon guidance, and neuronal development in multiple organisms.
bioRxiv · May 6, 2023 · PreprintNeuroscience