Owen J. Marshall

damidBind provides tools for differential DamID analysis and data exploration to identify differentially bound loci and transcribed genes between cell types.

The paper shows that oncogenic outcomes of dedifferentiation in Drosophila CNS vary by region, mediated by Chinmo and ecdysone signaling.

This study identifies the transcription factor Cph as promoting intestinal stem cell proliferation and endocrine differentiation in Drosophila, with implications for tumorigenesis and aging.

The paper shows that GAL4 driver expression in Drosophila declines rapidly with age, with some drivers losing activity within 30 days.

This study identifies KDM5's role in regulating mitochondrial gene expression in Drosophila prothoracic gland cells, showing its necessity for viability and highlighting its potential involvement in related disorders.

The paper shows Notch signaling differentially specifies L4 and L5 Drosophila lamina neuron fates by modulating Bsh's chromatin accessibility and gene activation.

This paper develops and validates an optogenetic tool, PiGM-Iq, to inhibit Gq signaling and demonstrates its effects on behavior, axon guidance, and neuronal development in multiple organisms.

The paper identifies eight chromatin states in Drosophila that segregate the genome into developmental and housekeeping roles through chromatin protein and histone mark associations.

This study shows that dedifferentiation-derived neural stem cells (NSCs) fail to express late temporal transcription factors, leading to impaired neuronal diversity and cell cycle progression.

This study shows that KDM5 is required in specific Drosophila brain cells for proper mushroom body formation and cognitive function, with Pros acting downstream of KDM5 to regulate neurodevelopment.

The paper introduces FlyORF-TaDa, a system that rapidly generates transgenic Drosophila lines for cell-type specific profiling of protein-DNA interactions using existing FlyORF libraries.

This study identifies AGO1 as a tumour suppressor in Drosophila that represses Myc transcription, inhibiting cell and tissue growth through direct transcriptional repression.

The paper identifies Psi as a repressor of developmental pathways that promotes Drosophila wing growth by both activating Myc and repressing growth inhibitors.

The paper introduces new TaDa vectors that enable simultaneous profiling of protein-DNA interactions and visualization of expression domains using membrane-bound GFP or mCherry labels.