Author

Andrew T. Watt

Ionis Pharmaceuticals (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Ashley Dung· 1 shared Audrey LowiD· 1 shared Christopher J. Torio· 1 shared Clare R. Quirk· 1 shared Colleen Y. Heller· 1 shared Dan DominissiniiD· 1 shared Dorothy T. Ta· 1 shared Eric E. SwayzeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Ashley Dung

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Author profile →

2 papers

Recent·Most cited

ASXL3 truncating patient variants mediate transcriptional gain-of-function and are antisense oligonucleotide-responsive

Yuji Nakamura, Toan Nguyen, Nofar Mor, Dan Dominissini, Isaac Tang, Christopher J. Torio, Harikrishna Thulaseedharan, Rachel Yibei Zhou, Wenshu Zhang, Konstantina Skourti-Stathaki, Julie Douville, Laurence Mignon, Ashley Dung, Susan M. Freier, Andrew T. Watt, , Joseph G. Gleeson

The paper shows ASXL3 truncating variants cause disease via gain-of-function, not loss-of-function, and demonstrates antisense oligonucleotides can reverse the transcriptional effects.

medRxiv · Jul 22, 2026 · PreprintGenetic & Genomic Medicine

Tuning siRNA Specificity through Seed Region Incorporation of Deoxyribonucleotide Stereoisomers

Mehran Nikan, Thazha P. Prakash, Guillermo Vasquez, Graeme C. Freestone, Marie Annoual, Michael Tanowitz, Hongda Li, Sagar S. Damle, Rodrigo Galindo‐Murillo, Stephanie K. Klein, Audrey Low, Clare R. Quirk, Colleen Y. Heller, Dorothy T. Ta, Andrew T. Watt, , Eric E. Swayze

This paper introduces modified nucleosides in siRNA seed regions to enhance specificity and reduce off-target effects while maintaining on-target activity.

bioRxiv · Jan 14, 2026 · PreprintMolecular Biology