Author

Michael Tanowitz

Ionis Pharmaceuticals (United States)ORCID 0009-0005-0509-4186Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Stephanie K. KleiniD· 3 shared Thazha P. PrakashiD· 3 shared Eric E. SwayzeiD· 2 shared Mehran NikaniD· 2 shared Rodrigo Galindo‐MurilloiD· 2 shared Alfred E. ChappelliD· 1 shared Andrew RodrigueziD· 1 shared Andrew T. Watt· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Stephanie K. KleinORCID

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3 papers

Recent·Most cited

NeuroscienceMolecular Therapy — Nucleic AcidsPeer-reviewedSep 18, 2026

Systemic and Local Delivery of siRNA to the CNS and Periphery via Anti-IGF1R Antibody Conjugation

Mengnan Tian, Mehran Nikan, Miran Yoo…·Sungwon An

This study develops an siRNA-antibody conjugate targeting IGF1R for systemic and CNS delivery, showing effective knockdown in multiple tissues and good tolerability.

DOI 10.1016/j.omtn.2026.103105

experimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 20, 2026

Delivery of small interfering RNA and antisense oligonucleotides across the blood-brain barrier with monovalent transferrin receptor 1 binding VHH-Fc fusion proteins

Ian J. Huggins, Michele Carrer, Jinro A. Santos…·Eric E. Swayze

This paper develops a VHH-Fc fusion protein to deliver siRNAs and ASOs across the BBB in rodents and NHPs, showing that binding affinity, DAR, and conjugation site affect delivery efficiency.

DOI 10.64898/2026.08.13.744307

mousenon-human primate

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Molecular BiologybioRxivPreprintJan 14, 2026

Tuning siRNA Specificity through Seed Region Incorporation of Deoxyribonucleotide Stereoisomers

Mehran Nikan, Thazha P. Prakash, Guillermo Vasquez…·Eric E. Swayze

This paper introduces modified nucleosides in siRNA seed regions to enhance specificity and reduce off-target effects while maintaining on-target activity.

DOI 10.64898/2026.01.13.699368

experimental assaydrug response / drug discovery

𝕏 PostBluesky