Cardiomyocyte-specific expression of HIF-1α mediates the cardioprotective effects of Growth Hormone-Releasing Hormone (GHRH)
Rosemeire M. Kanashiro‐Takeuchi, Lauro Mitsuru Takeuchi, Wayne Balkan, Karina Dutra Asensi, Raúl A Dulce, Amarylis Claudine Bonito Azeredo Wanschel, Konstantinos E. Hatzistergos, Shathiyah Kulandavelu, Russell Saltzman, Lina A. Shehadeh, Wei Sha, Andrew V. Schally, Stefan Kurtenbach, Joshua M. Hare
This study identifies the HIF-1 pathway as mediating the cardioprotective effects of GHRH-agonists in a murine model of cardiometabolic HFpEF.
American Journal of Physiology-Heart and Circulatory Physiology · Aug 1, 2026Peer-reviewedPhysiology