Non cell-autonomous effect of astrocytes on cerebral cavernous malformations
Miguel Alejandro Lopez‐Ramirez, Shady Ibrahim Soliman, Preston Hale, Catherine Chinhchu Lai, Angela Pham, Esau J. Estrada, Sara McCurdy, Romuald Girard, Riya Verma, Thomas Moore, Rhonda Lightle, Nicholas Hobson, Robert Shenkar, Orit Poulsen, Gabriel George Haddad, , Mark H. Ginsberg
The paper shows that astrocytes contribute to cerebral cavernous malformations (CCMs) through VEGF production driven by endothelial NO, highlighting non-cell-autonomous mechanisms.
bioRxiv · Jan 29, 2021 · PreprintNeuroscience