Toll-like Receptor 4 Contributes to PCOS-like Metabolic and Reproductive Pathogenesis
Kiara Dominique Wiggins, Zena D. Del Mundo, Julio A Ayala Angulo, Nandini Naidu, Angelina Saba, Christopher Garcia, Christy M Nguyen, Naveena S. Ujagar, Jamie-Jean De La Torre, Gabriela De Robles, Angie Rivera, Davina Trinh, Roberto Tinoco, Alexander S. Kauffman, Varykina G. Thackray, , Dequina Nicholas
This study shows that TLR4 deficiency reduces PCOS-like symptoms in a mouse model by improving metabolic and reproductive health and reducing inflammation.
bioRxiv · Oct 16, 2025 · PreprintImmunology