Varykina G. Thackray

This study shows that TLR4 deficiency reduces PCOS-like symptoms in a mouse model by improving metabolic and reproductive health and reducing inflammation.

The paper identifies T cells and TNF-β as associated with PMOS-like phenotypes and shows T cells are necessary for letrozole-induced LH elevation in a mouse model.

This study uses a genetic hypogonadal mouse model to show that the HPG axis influences gut microbiome maturation during puberty, with some sex differences independent of the HPG axis and age also playing a role.