Christy M Nguyen

Dp16 mice, carrying 115 triplicated Hsa21 orthologs, show sex-shared insulin resistance, glucose intolerance and dyslipidemia, worsened by high-fat diet, with multi-tissue transcriptome and metabolome signatures.

This study shows that TLR4 deficiency reduces PCOS-like symptoms in a mouse model by improving metabolic and reproductive health and reducing inflammation.

The paper identifies a novel antiphage system, Panoptes, that uses a minimal CRISPR polymerase to produce cyclic nucleotides and detects phage anti-defense proteins through effector binding and nucleotide depletion.

The paper identifies T cells and TNF-β as associated with PMOS-like phenotypes and shows T cells are necessary for letrozole-induced LH elevation in a mouse model.