Author

Julio A Ayala Angulo

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Dequina NicholasiD· 4 shared Naveena S. UjagariD· 4 shared Gabriela De Robles· 3 shared Kiara Dominique WigginsiD· 3 shared Zena D. Del MundoiD· 3 shared Alexander S. KauffmaniD· 2 shared Christy M NguyeniD· 2 shared Marcus Michael SeldiniD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Dequina NicholasORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Endocrine-Adapted Pituitary Macrophages Regulate Gonadotropin Secretion through CXCL5-CXCR2-MAPK Signaling

Zena D. Del Mundo, Jocelyn Ha, Lily Zhou, Antonia Zhang, Gabriela De Robles, Kiara Dominique Wiggins, Kien Pham, Naveena S. Ujagar, Julio A Ayala Angulo, Karen Tonsfeldt, Stephanie Correa, J. Edward van Veen, Dorota Skowronska‐Krawczyk, Dequina Nicholas

The paper identifies pituitary macrophages as hormone-producing immune cells that regulate gonadotropin secretion through CXCL5-CXCR2-MAPK signaling in female mice.

bioRxiv · Aug 20, 2026 · PreprintImmunology

Toll-like Receptor 4 Contributes to PCOS-like Metabolic and Reproductive Pathogenesis

Kiara Dominique Wiggins, Zena D. Del Mundo, Julio A Ayala Angulo, Nandini Naidu, Angelina Saba, Christopher Garcia, Christy M Nguyen, Naveena S. Ujagar, Jamie-Jean De La Torre, Gabriela De Robles, Angie Rivera, Davina Trinh, Roberto Tinoco, Alexander S. Kauffman, Varykina G. Thackray, , Dequina Nicholas

This study shows that TLR4 deficiency reduces PCOS-like symptoms in a mouse model by improving metabolic and reproductive health and reducing inflammation.

bioRxiv · Oct 16, 2025 · PreprintImmunology

Phollow: Visualizing Gut Bacteriophage Transmission within Microbial Communities and Living Animals

Lizett Ortiz de Ora, Elizabeth T. Wiles, Mirjam Zünd, Maria S. Bañuelos, Nancy Haro-Ramirez, Diana S. Suder, Naveena S. Ujagar, Julio A Ayala Angulo, Calvin Trinh, Courtney Knitter, Shane Gonen, Dequina Nicholas, Travis J. Wiles

Phollow tracks phage replication and spread in zebrafish guts with single-virion resolution, revealing rapid uptake by intestinal cells and antibiotic-induced shifts in microbial communities.

Nature Microbiology · Apr 18, 2025Peer-reviewedMicrobiology

Systems Genetics Cytokine Screen Identifies T cells as Necessary for Letrozole-Induced LH Elevation in a PMOS-like Mouse Model

Naveena S. Ujagar, Leandro M. Vélez, Christy M Nguyen, Kiara Dominique Wiggins, Gabriela De Robles, Zena D. Del Mundo, Siaje Gideon, Jessica Cassin, Joshua Kim, Nandini Naidu, Julio A Ayala Angulo, Benjamin Babaev, A Dingle, Margareta Danuta Pisarska, Ricardo Azziz, , Dequina Nicholas

The paper identifies T cells and TNF-β as associated with PMOS-like phenotypes and shows T cells are necessary for letrozole-induced LH elevation in a mouse model.

bioRxiv · Jan 8, 2025 · PreprintImmunology