A human iPSC-derived motor neuron-myogenic cell coculture platform to evaluate neuromuscular junction innervation after axon injury and in Spinal Muscular Atrophy
Keunjung Heo, Xiangsunze Zeng, Kathleen Zhang, Kuchuan Chen, Shannon Zhen, Anika Naveen, Richard M. Giadone, Rasheen Powell, Roshan Pandey, Lee L. Rubin, Clifford J. Woolf
This paper develops a human iPSC-derived motor neuron-myogenic coculture platform to study NMJ innervation after axon injury and in SMA, showing blebbistatin enhances NMJ reinnervation and confirming reduced NMJ function in SMA patient-derived neurons.
bioRxiv · Oct 17, 2025 · PreprintNeuroscience