Author

Kuchuan Chen

Boston Children's HospitalORCID 0000-0002-8206-482XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Clifford J. WoolfiD· 4 shared Riki KawaguchiiD· 3 shared Roshan Pandey· 3 shared Daniel H. GeschwindiD· 2 shared Devlin FrostiD· 2 shared Laura Perrault· 2 shared Rasheen PowelliD· 2 shared Shannon ZheniD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersNeuroscience

Clifford J. WoolfORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

Caiwei Guo, Kuchuan Chen, Sarat C. Vatsavayai, Tetsuya Akiyama, Chang Liu, Yi Zeng, Odilia Sianto, Edith Yang, Juliane Bombosch, Rasheen Powell, Shannon Zhen, Shila Mekhoubad, Ryan D. Morrie, Georgiana Miller, Dragana Ilic, , Aaron D. Gitler

This study identifies TDP-43-dependent cryptic splicing events in synaptic and membrane excitability genes and shows they drive neuronal dysfunction in ALS and FTD.

Science Translational Medicine · Jun 3, 2026Peer-reviewedNeuroscience

A human iPSC-derived motor neuron-myogenic cell coculture platform to evaluate neuromuscular junction innervation after axon injury and in Spinal Muscular Atrophy

Keunjung Heo, Xiangsunze Zeng, Kathleen Zhang, Kuchuan Chen, Shannon Zhen, Anika Naveen, Richard M. Giadone, Rasheen Powell, Roshan Pandey, Lee L. Rubin, Clifford J. Woolf

This paper develops a human iPSC-derived motor neuron-myogenic coculture platform to study NMJ innervation after axon injury and in SMA, showing blebbistatin enhances NMJ reinnervation and confirming reduced NMJ function in SMA patient-derived neurons.

bioRxiv · Oct 17, 2025 · PreprintNeuroscience

NEK1 modulates neurite outgrowth in motor neurons through coordinating retromer formation

Xuan Huang, Juan A. Osés-Prieto, Riki Kawaguchi, Laura Perrault, Devlin Frost, Kuchuan Chen, Feng Guo, Bingjie Zhang, Pinghan Zhao, Tammy Szu‐Yu Ho, Roshan Pandey, Daniel H. Geschwind, Alma L. Burlingame, Clifford J. Woolf

This study identifies NEK1's role in motor neuron neurite outgrowth by coordinating retromer formation through interactions with SMC3.

bioRxiv · May 6, 2024 · PreprintNeuroscience

Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability

Xuan Huang, Seungkyu Lee, Riki Kawaguchi, Ole Wiskow, Sulagna Dia Ghosh, Devlin Frost, Laura Perrault, Roshan Pandey, Kuchuan Chen, Joseph R. Klim, Bruno Boivin, Crystal Hermawan, Kenneth J. Livak, Dan H. Geschwind, Brian J. Wainger, , Clifford J. Woolf

The paper shows that reduced Kv8.1 expression in ALS motor neurons with SOD1(A4V) and C9orf72 mutations increases vulnerability to cell death by affecting metabolism and transport pathways.

bioRxiv · May 7, 2023 · PreprintNeuroscience

Screening for axon regeneration promoting compounds with human iPSC-derived motor neurons

Tammy Szu‐Yu Ho, J. Tabitha Hees, Zhuqiu Xu, Riki Kawaguchi, Natália P. Biscola, Daniel G. Taub, Kuchuan Chen, Xirui Chen, Lee B Barrett, Long Cheng, Christopher V. Gabel, Leif A. Havton, Daniel H. Geschwind, Clifford J. Woolf

This study identifies compounds that promote axon regeneration using human iPSC-derived motor neurons and validates blebbistatin as a top hit in vivo.

bioRxiv · Nov 2, 2021 · PreprintNeuroscience