Xiangsunze Zeng

Targeting Gi/o-coupled GPCRs to inhibit nociceptors: insights from the serotonin receptor Htr1b and triptans

The paper identifies Gi/o-coupled GPCRs in nociceptors and shows that Htr1b agonists like triptans reduce neuronal excitability and pain in models, suggesting new analgesic targets.

A human iPSC-derived motor neuron-myogenic cell coculture platform to evaluate neuromuscular junction innervation after axon injury and in Spinal Muscular Atrophy

This paper develops a human iPSC-derived motor neuron-myogenic coculture platform to study NMJ innervation after axon injury and in SMA, showing blebbistatin enhances NMJ reinnervation and confirming reduced NMJ function in SMA patient-derived neurons.

A genetically defined injured C-fibre nociceptor associated with neuromasdrives chronic spontaneous neuropathic pain

The paper identifies a specific subtype of injured C-fibre nociceptors in neuromas that drive chronic spontaneous neuropathic pain in mice.

Machine learning behavioral analysis reveals cervical instability as an early biomarker of Amyotrophic Lateral Sclerosis

This paper uses machine learning to detect early cervical instability in ALS mice, identifying it as a behavioral biomarker for early disease detection.

Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in Drosophila larvae

The paper shows that Wnt/Fz signaling regulates segment-specific axon guidance in Drosophila larvae, diversifying motor commands for forward and backward locomotion.

Selective modification of ascending spinal outputs in acute and neuropathic pain states

The paper examines how spinal nociceptive output changes in acute and neuropathic pain states using calcium imaging.