Roshan Pandey

A human iPSC-derived motor neuron-myogenic cell coculture platform to evaluate neuromuscular junction innervation after axon injury and in Spinal Muscular Atrophy

This paper develops a human iPSC-derived motor neuron-myogenic coculture platform to study NMJ innervation after axon injury and in SMA, showing blebbistatin enhances NMJ reinnervation and confirming reduced NMJ function in SMA patient-derived neurons.

From resting state to inactivation: the dynamic journey of the inactivation peptide in Shaker Kv channels

The paper tracks the movement of the inactivation peptide in Shaker Kv channels during N-type inactivation using voltage clamp fluorometry and FRET techniques, revealing a biphasic mechanism involving release and pore blockage.

NEK1 modulates neurite outgrowth in motor neurons through coordinating retromer formation

This study identifies NEK1's role in motor neuron neurite outgrowth by coordinating retromer formation through interactions with SMC3.

Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability

The paper shows that reduced Kv8.1 expression in ALS motor neurons with SOD1(A4V) and C9orf72 mutations increases vulnerability to cell death by affecting metabolism and transport pathways.

Cannabidiol activates neuronal Kv7 channels

This study identifies CBD's activation of Kv7 channels as a mechanism for its antiepileptic effects.