The TIRR-53BP1 axis controls PLK1 spatiotemporal regulation during mitosis
Aniruddha Sarkar, Shrabasti Roychoudhury, Katherine N. Choe, Neil T. Umbreit, H. Rudolf de Boer, Yizhou Joseph He, Bartłomiej Tomasik, Marcel A.T.M. van Vugt, David S. Pellman, Dipanjan Chowdhury, Alexander Spektor
This study shows that the TIRR-53BP1 axis regulates PLK1 activity during mitosis, affecting chromosome segregation and kinetochore assembly.
bioRxiv · Jun 30, 2026 · PreprintCell Biology