Dipanjan Chowdhury

The TIRR-53BP1 axis controls PLK1 spatiotemporal regulation during mitosis

This study shows that the TIRR-53BP1 axis regulates PLK1 activity during mitosis, affecting chromosome segregation and kinetochore assembly.

H3K27M-driven hypertranscription leads to a new targetable dependency in diffuse midline gliomas

This study identifies hypertranscription as a vulnerability in H3K27M-driven diffuse midline gliomas, showing ATR inhibition effectively targets this feature in preclinical models.

Human CDK5-cyclin B1 structures uncover a conserved mitotic CDK activation mechanism

The paper determines the first high-resolution crystal structures of CDK5-cyclin B1, revealing its mitotic activation mechanism similar to CDK1-cyclin B1.

Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents

The paper identifies USP48 as a regulator of chromatin stability and DNA damage response to hypomethylating agents, showing its loss increases susceptibility to these drugs in AML.

Dynamics of the DYNLL1/MRE11 complex regulates DNA end resection and recruitment of the Shieldin complex to DSBs

This study shows how DYNLL1 and Shieldin regulate DNA end resection and repair pathway choice through interactions with MRE11 and 53BP1 at DSBs.

OmicSelector: automatic feature selection and deep learning modeling for omic experiments.

OmicSelector automates feature selection and deep learning modeling for omic experiments, identifying overfitting-resistant biomarker sets with high diagnostic potential.