Marcel A.T.M. van Vugt

The paper shows that chromosomal instability (CIN) leads to distinct p21-expressing cell populations with different cell-cycle recovery and extracellular vesicle (EV) properties, resulting in increased migration.

This study shows that CIP2A tetramerization is essential for mitotic DNA repair and survival of BRCA1/2 mutant cancer cells.

This study shows that the TIRR-53BP1 axis regulates PLK1 activity during mitosis, affecting chromosome segregation and kinetochore assembly.

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

The paper shows that transposable element derepression triggers IFN-I signaling, boosting stem/progenitor cell activity after irradiation.

This study identifies TAOK1 as a regulator of replication fork stability in BRCA1/2-deficient tumors, showing it enhances sensitivity to PARPi and IR through PCNA and ISG15 interactions.

The paper shows that increased PRMT5-MEP50 complex activity helps aneuploid cancer cells survive by reducing protein aggregation and proteotoxicity.

This study shows that CIP2A-TOPBP1 recruits the SMX tri-nuclease complex to resolve mitotic DNA lesions, ensuring genome integrity and survival of BRCA2-deficient cells.

This study investigates the acute effects of CAF-1 loss on chromatin assembly during S-phase, revealing multi-level responses including replication slowdown and histone modification changes.

This study identifies FANCL and Ube2T as HR-promoting factors at DSBs and shows they regulate CtIP recruitment and end-resection for homologous recombination.

The paper identifies HDAC4 as a synthetic lethal target in MELK-overexpressing cancers through a yeast screen and mammalian validation.