Lenacapavir-induced capsid damage exposes HIV-1 genomes from nuclear speckles.
Thorsten G. Müller, Severina Klaus, Vojtěch Žíla, Bojana Lucic, Carlotta Penzo, Svenja L. Nopper, Gonen Golani, Maria Anders‐Össwein, Vera Sonntag-Buck, Anke‐Mareil Heuser, Ulrich S. Schwarz, Vibor Laketa, Marina Lušić, Bárbara Müller, Hans‐Georg Kräusslich
This study shows Lenacapavir causes HIV-1 capsid damage, exposing genomic DNA in nuclear speckles and altering capsid structure.
The EMBO Journal · Dec 1, 2025Peer-reviewedMicrobiology