Marina Lušić

CpG methylation and methionine metabolism account for phenotypic bifurcation of HIV transcription: a unique case of a pure epigenetic phenomenon

The paper identifies CpG methylation and methionine metabolism as factors contributing to phenotypic bifurcation in HIV transcription, suggesting a pure epigenetic mechanism.

Molecular architecture of heterochromatin at the nuclear periphery of primary human cells

This study uses in situ structural biology to reveal the molecular organization of chromatin at the nuclear periphery in human cells.

Lenacapavir-induced capsid damage exposes HIV-1 genomes from nuclear speckles.

This study shows Lenacapavir causes HIV-1 capsid damage, exposing genomic DNA in nuclear speckles and altering capsid structure.

Nucleoporin Nup153 docks the splicing machinery to the nuclear pore for efficient mRNA processing

This study identifies Nup153 as a docking point for splicing machinery at the nuclear pore, showing its role in mRNA processing and gene splicing.

Genomic profiling of HIV-1 integration in microglia links viral insertions to TAD organization

This study profiles HIV-1 integration sites in microglia and links viral insertions to topologically associated domain organization.

Alterations of redox and iron metabolism accompany development of HIV latency.

The paper identifies alterations in redox and iron metabolism associated with HIV-1 latency development and suggests iron metabolism modulators as potential therapeutic tools.

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1

The paper identifies spatially clustered genes with multiple enhancers as frequent targets of HIV-1 integration in T cells.

Hypoxic environment promotes barrier formation in human intestinal epithelial cells through regulation of miRNA-320a expression

This study identifies miRNA-320a as a hypoxia-regulated factor that promotes barrier formation in human intestinal epithelial cells through HIF-dependent mechanisms.