Oncodevelopmental plasticity of the skeleton in myeloid neoplasms
Salim Atakhanov, Ian Ghezzi, Hector Tejeda Mora, Lucas Greven, Marta Rizk, Lina Schmidt, Katrin Goetz, Lina Merg, Valeria Solozobova, Adam Benabid, Pia Wanner, Niklas Lutterbach, Aleksandar V. Kargaliev, Mathias Schäfersküpper, Alexandru Florea, , Rebekka K. Schneider
This study identifies a novel mechanism in myelofibrosis where a single mutation drives both bone formation and resorption, revealing THBS1 as a therapeutic target.
bioRxiv · Mar 21, 2026 · PreprintCancer Biology