Melanie Generali

This paper develops a 3D hydrogel scaffold platform to guide human neuromuscular tissue architecture and function, showing improved myotube alignment, axon guidance, and functional connectivity.

Stimulatrix automates the functional analysis of engineered muscle tissues using video acquisition, electrical stimulation, and deep learning to quantify contractile properties over time.

This study shows that using a dual safety switch to eliminate neural grafts after stroke impairs functional recovery despite effective cell ablation.

This paper develops CAR-NSC therapy targeting integrin αvβ3 to improve spatial distribution and tissue engagement of transplanted cells in stroke models.

This paper describes a method to generate valvular interstitial cells from human pluripotent stem cells, showing high transcriptional similarity to primary fetal VICs and recapitulating disease features in an in vitro model.

This study shows that hypoxic preconditioning of human iPSC-derived neural progenitor cells improves their survival and function after transplantation in a stroke mouse model.

This study shows that transplanting iPSC-derived neural progenitor cells improves long-term recovery after stroke in mice by promoting tissue repair and reducing neurological deficits.

This paper develops a cardiac tissue patch (RCPatch) using 3D printing and melt-electrowriting that withstands mechanical stress and promotes hemodynamic recovery in animal trials.

This paper develops xeno-free iPSC-derived NPCs compatible with GMP for clinical use, showing long-term survival and differentiation into neurons in vivo.