Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation
Sydney J. Tomlinson, Sean L. Johnson, Anna H. Kroskrity, Yun Hu, Kirandeep K. Deol, Cynthia Y. Zhang, Cynthia A. Harris, Daniel K. Nomura, James A. Olzmann
This paper demonstrates that ER membrane proteins can be degraded via cytosolic E3 ligase recruitment, bypassing ERAD and relying on VCP-mediated ubiquitin chain cleavage.
bioRxiv · Nov 28, 2025 · PreprintCell Biology