Author

Sean L. Johnson

University of California, BerkeleyORCID 0000-0002-7149-6563Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

James A. OlzmanniD· 2 shared Anna H. Kroskrity· 1 shared Benjamin S. StyleriD· 1 shared Cody E. DoubravskyiD· 1 shared Cynthia A. HarrisiD· 1 shared Cynthia A. Harris· 1 shared Cynthia Y. Zhang· 1 shared Daniel K. NomuraiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

James A. OlzmannORCID

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2 papers

Recent·Most cited

Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation

Sydney J. Tomlinson, Sean L. Johnson, Anna H. Kroskrity, Yun Hu, Kirandeep K. Deol, Cynthia Y. Zhang, Cynthia A. Harris, Daniel K. Nomura, James A. Olzmann

This paper demonstrates that ER membrane proteins can be degraded via cytosolic E3 ligase recruitment, bypassing ERAD and relying on VCP-mediated ubiquitin chain cleavage.

bioRxiv · Nov 28, 2025 · PreprintCell Biology

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis

Mike Lange, Michele Wölk, Vivian Wen Li, Cody E. Doubravsky, Joseph M. Hendricks, Shunji Kato, Yurika Otoki, Benjamin S. Styler, Sean L. Johnson, Cynthia A. Harris, Kiyotaka Nakagawa, Isabel Faria Snodgrass, Do‐Hee Kim, John W. I. Newman, Maria Fedorova, James A. Olzmann

This study identifies FSP1 as a critical regulator of lipid droplet quality control, preventing neutral lipid peroxidation and ferroptosis by recycling CoQ10.

Nature Cell Biology · Oct 29, 2025Peer-reviewedCell Biology