Loss of the mitochondrial carrier, SLC25A1, during embryogenesis induces a unique senescence program controlled by p53
Anna Kasprzyk-Pawelec, Mingjun Tan, Raneen Rahhal, Alec T. McIntosh, Harvey R. Fernandez, Rami Mosaoa, Lei Jiang, Gray W. Pearson, Eric F. Glasgow, Jerry E. Vockley, Christopher Albanese, Maria Laura Avantaggiati
This study shows that SLC25A1 deficiency in mice causes senescence via p53-dependent pathways, leading to developmental disorders similar to human D/L-2HGA.
bioRxiv · Jul 18, 2023 · PreprintDevelopmental Biology