Rami Mosaoa

Tumor intrinsic regulation of PD-L1 and of interferon Type I via an SLC25A1-driven mitochondrial pathway, influences the anti-tumor immune response

This study identifies SLC25A1 as a regulator of PD-L1 and type I interferon signaling via a mitochondrial pathway, influencing tumor immune response and immunotherapy efficacy.

Loss of the mitochondrial carrier, SLC25A1, during embryogenesis induces a unique senescence program controlled by p53

This study shows that SLC25A1 deficiency in mice causes senescence via p53-dependent pathways, leading to developmental disorders similar to human D/L-2HGA.