Alec T. McIntosh

Impact of Trastuzumab and Pertuzumab on HER2 Localization and the Estrogen Receptor Cistrome in ER+/HER2+ Breast Cancer

This study examines how anti-HER2 therapy affects HER2 localization and ER genomic binding in ER+/HER2+ breast cancer, finding ER redistribution correlates with treatment resistance.

N-cadherin facilitates trigeminal sensory neuron outgrowth and target tissue innervation

This study shows that N-cadherin is essential for trigeminal ganglion development, axon outgrowth, and target innervation by placodal and neural crest-derived neurons.

The transcriptional landscape of the developing chick trigeminal ganglion

This study uses RNA-sequencing to analyze chick trigeminal ganglion development, identifying key pathways in gangliogenesis and neuron maturation.

Loss of the mitochondrial carrier, SLC25A1, during embryogenesis induces a unique senescence program controlled by p53

This study shows that SLC25A1 deficiency in mice causes senescence via p53-dependent pathways, leading to developmental disorders similar to human D/L-2HGA.

A genomic variant of ALPK2 is associated with increased liver fibrosis risk in HIV/HCV coinfected women

The paper identifies a genomic variant in ALPK2 associated with increased liver fibrosis risk in HIV/HCV coinfected women using clinical data from the WIHS cohort.