Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by in vitro Cellular Studies and in vivo PET Imaging
Hannah J. Zhang, Matthew D. Zammit, Chien-Min Kao, Anitha P. Govind, Samuel J. Mitchell, Nathanial Holderman, Mohammed P. I. Bhuiyan, Richard H. Freifelder, Anna Kucharski, Xiaoxi Zhuang, Jogeshwar Mukherjee, Chin-Tu Chen, William N. Green
The paper investigates how nicotine and varenicline distribute in brain cells by combining in vitro and in vivo imaging, finding that varenicline is trapped in 4{beta}2R-containing Golgi satellites, leading to slow release.
Journal of Neuroscience · Aug 26, 2022Peer-reviewedNeuroscience