Anitha P. Govind

This paper develops a human-based translational activator to restore protein expression in a Dravet syndrome mouse model, showing improved survivability and seizure threshold.

The paper investigates how nicotine and varenicline distribute in brain cells by combining in vitro and in vivo imaging, finding that varenicline is trapped in 4{beta}2R-containing Golgi satellites, leading to slow release.

The paper shows that increased neuronal excitation leads to the formation of Golgi satellites in dendrites, which modify surface glycoproteins and impact neurotransmitter receptor function.

This study shows that nicotine exposure and neuronal activity alter Golgi membrane distribution in neurons, affecting local trafficking and potentially contributing to addiction.