Xiaoxi Zhuang

This study shows that YTHDF1 mediates m6A mRNA methylation in neuronal adaptation to environmental challenges, with distinct roles in D1 and D2 neurons.

This study shows that PNPO in GABAergic neurons is cell-autonomous for maintaining brain function and suppressing seizures in Drosophila under vitamin B6 restriction.

This study investigates how genetic vitamin B6 deficiency interacts with alcohol consumption in Drosophila, showing altered behavior and metabolism, with potential therapeutic implications.

The paper identifies distinct memory storage in the direct and indirect basal ganglia pathways, showing normal motor memory is preserved in the direct pathway while aberrant inhibitory memory is stored in the indirect pathway.

This study shows that FMRP phosphorylation regulates neuronal translation via YTHDF1, revealing a mechanism for FXS pathology and suggesting YTHDF1 as a therapeutic target.

The paper investigates how nicotine and varenicline distribute in brain cells by combining in vitro and in vivo imaging, finding that varenicline is trapped in 4{beta}2R-containing Golgi satellites, leading to slow release.

This study shows that PNPO variants in Drosophila interact with diet to produce diverse phenotypes, including seizures and lethality, and highlights the utility of a knock-in model for studying human PNPO deficiency.

The paper shows that inducing LTD in corticostriatal inputs to indirect pathway neurons in a Parkinsonian mouse model leads to prolonged relief of motor symptoms.

This study identifies syp as a gene regulating Starvation-Induced Hyperactivity in Drosophila through RNA-binding protein function and alternative splicing.

This study shows that nicotine exposure and neuronal activity alter Golgi membrane distribution in neurons, affecting local trafficking and potentially contributing to addiction.

This study establishes Drosophila models of PNPO deficiency, showing seizures and lethality linked to low PLP levels, and demonstrates functional conservation between human and fly PNPO.