Endothelial CLK2 as a therapeutic target for acute radiation syndrome
Ryan R. Posey, Aliçan Özkan, Yuncheng Man, Jéssica F. Feitor, Amanda R. Jiang, Jie Ji, Nina LoGrande, Christos Kyprianou, Anna M. Howley, Bogdan Budnik, Jonathan D. Lee, David Benson Chou, Donald E. Ingber
This study identifies CLK2 as a therapeutic target for acute radiation syndrome by showing CLK2 inhibitors protect endothelial cells and reverse radiation injury in human organ models.
bioRxiv · Nov 5, 2025 · PreprintMolecular Biology