David Benson Chou

Tumor suppressor-like mutations mark a dosage-constrained dependency in leukemia

The paper shows that oncogene-imposed dosage constraints can lead to mutations resembling tumor suppressor loss, which are essential in APL.

Human fallopian tube-on-a-chip for preclinical testing of non-hormonal contraceptives with living human sperm

The paper develops a human fallopian tube-on-a-chip model to test non-hormonal contraceptives, showing dose-dependent sperm motility inhibition by TDI-11861.

Endothelial CLK2 as a therapeutic target for acute radiation syndrome

This study identifies CLK2 as a therapeutic target for acute radiation syndrome by showing CLK2 inhibitors protect endothelial cells and reverse radiation injury in human organ models.

Induction of cervical dysfunction associated with preterm birth by IL-1 and dysbiotic microbiome revealed in human endocervix chips

The paper uses human endocervix chips to show that IL-1 receptor antagonists may prevent preterm labor by reducing cervical dysfunction.