Retinal ganglion cells harboring the OPTN(E50K) glaucoma mutation exhibit neurodegenerative phenotypes when derived from hPSC-derived three dimensional retinal organoids
Kirstin B. VanderWall, Kang-Chieh Huang, Yanling Pan, Sailee Sham Lavekar, Clarisse M. Fligor, Anna R. Allsop, Kelly Lentsch, Pengtao Dang, Chi Zhang, Henry C. Tseng, Theodore Cummins, Jason S. Meyer
This study shows that hPSC-derived RGCs with the OPTN(E50K) mutation display neurodegenerative phenotypes, providing insights into glaucoma mechanisms.
Stem Cell Reports · Jun 11, 2020Peer-reviewedNeuroscience