Sailee Sham Lavekar

A human pluripotent stem cell tri-culture platform to elucidate microglial regulation of retinal ganglion cells in neuroinflammation

This study uses a human pluripotent stem cell tri-culture system to investigate how microglia influence retinal ganglion cell health and disease in neuroinflammation.

Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms

This study uses microfluidic platforms to model human retinal ganglion cell compartmentalization, showing axonal deficits in disease and astrocyte reactivity-induced neurodegeneration.

Autophagy Disruption Reduces mTORC1 Activation Leading to Retinal Ganglion Cell Neurodegeneration Associated with Glaucoma

This study shows that autophagy disruption reduces mTORC1 activation, leading to retinal ganglion cell degeneration in glaucoma, and identifies potential therapeutic targets.

Human Astrocytes Synchronize Neural Organoid Networks

This study shows astrocytes enhance synchronized activity in neural organoids and demonstrate that amyloid inhibition can be rescued by neighboring network activity.

Retinal ganglion cells harboring the OPTN(E50K) glaucoma mutation exhibit neurodegenerative phenotypes when derived from hPSC-derived three dimensional retinal organoids

This study shows that hPSC-derived RGCs with the OPTN(E50K) mutation display neurodegenerative phenotypes, providing insights into glaucoma mechanisms.