Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome
Florian A. Rosenberger, Marvin Thielert, Maximilian T. Strauss, Lisa Schweizer, Constantin Ammar, Sophia Clara Mädler, Andreas Metousis, Patricia Skowronek, Maria Wahle, Katherine Madden, Janine Gote-Schniering, Anna Semenova, Herbert B. Schiller, Edwin H. Rodriguez, Thierry M. Nordmann, , Matthias Mann
The paper introduces scDVP, a spatial single-cell proteomics method, and finds that half of the murine hepatocyte proteome varies spatially within liver tissue.
Nature Methods · Oct 1, 2023Peer-reviewedSystems Biology