Thierry M. Nordmann

Cell-type-resolved spatial proteogenomics from matched genome and proteome of the same cells

The paper demonstrates a method to simultaneously measure genome and proteome from the same cells in archival FFPE tissue, applied to melanoma.

Spatial proteomics reveals mechanisms of cell-intrinsic tryptophan metabolism controlling ovarian cancer survival

The paper uses spatial proteomics to show IDO1's tumor-suppressive role in ovarian cancer by linking it to tryptophan metabolism and stress response pathways.

Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome

The paper introduces scDVP, a spatial single-cell proteomics method, and finds that half of the murine hepatocyte proteome varies spatially within liver tissue.

Robust dimethyl-based multiplex-DIA workflow doubles single-cell proteome depth via a reference channel

This paper introduces a multiplex-DIA workflow that enhances single-cell proteome depth using dimethyl labeling and a reference channel, achieving reliable quantification of nearly 4,000 proteins per cell.

Regulation of neuroinflammation by astrocyte-derived cholesterol.

This study shows that astrocyte-derived cholesterol, released via apoE, promotes neuroinflammation by enhancing inflammatory signaling in immune cells.