Herbert B. Schiller

Pertpy provides a modular framework for analyzing large-scale perturbation single-cell experiments, offering tools for metadata annotation and perturbation distance calculations.

This study uses single-cell RNA-sequencing to analyze how different nanomaterials affect lung inflammation in mice, identifying cell type-specific responses and mechanisms.

The paper introduces scDVP, a spatial single-cell proteomics method, and finds that half of the murine hepatocyte proteome varies spatially within liver tissue.

The paper uses peptide location fingerprinting to identify age- and disease-related structural changes in proteins across species and tissues.

The paper maps aging in the lung using single cell transcriptomics and proteomics, identifying novel age-related changes in cell types and the extracellular matrix.