Patricia Skowronek

Multimodal AI agents for capturing and sharing laboratory practice

This paper introduces a multimodal AI agent that captures and shares lab practice by integrating video, speech, and text analysis to improve reproducibility in proteomics.

AlphaDIA enables End-to-End Transfer Learning for Feature-Free Proteomics

AlphaDIA enables end-to-end transfer learning for feature-free proteomics, improving identification and quantification of post-translational modifications.

Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome

The paper introduces scDVP, a spatial single-cell proteomics method, and finds that half of the murine hepatocyte proteome varies spatially within liver tissue.

Robust dimethyl-based multiplex-DIA workflow doubles single-cell proteome depth via a reference channel

This paper introduces a multiplex-DIA workflow that enhances single-cell proteome depth using dimethyl labeling and a reference channel, achieving reliable quantification of nearly 4,000 proteins per cell.

AlphaViz: Visualization and validation of critical proteomics data directly at the raw data level

AlphaViz validates proteomics results by visualizing raw data and comparing with automated analysis outputs.

AlphaTims: Indexing trapped ion mobility spectrometry - time of flight data for fast and easy accession and visualization

AlphaTims enables fast access and visualization of high-dimensional LC-TIMS-QTOF proteomics data through efficient indexing and just-in-time compilation.