Lisa Schweizer

AI-powered Deep Visual Proteomics reveals critical molecular transitions in pancreatic cancer precursors

This study uses AI-driven proteomics to identify molecular transitions in pancreatic cancer precursors, revealing early molecular changes in histologically normal tissue.

Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome

The paper introduces scDVP, a spatial single-cell proteomics method, and finds that half of the murine hepatocyte proteome varies spatially within liver tissue.

Robust dimethyl-based multiplex-DIA workflow doubles single-cell proteome depth via a reference channel

This paper introduces a multiplex-DIA workflow that enhances single-cell proteome depth using dimethyl labeling and a reference channel, achieving reliable quantification of nearly 4,000 proteins per cell.

Integrated phospho-proteogenomic and single-cell transcriptomic analysis of meningiomas establishes robust subtyping and reveals subtype-specific immune invasion

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.

A streamlined mass spectrometry-based proteomics workflow forlarge scale FFPE tissue analysis

This paper presents a streamlined mass spectrometry-based proteomics workflow for analyzing FFPE tissue samples, demonstrating efficient and scalable proteome profiling of clinical specimens.